A Community of Rambunctious Scholars Celebrating People
Who Have Made Lifesaving Discoveries And Encouraging
Students and Politicians to Read 1000 Science Stories!

TOTAL LIVES SAVED
Nghe Nguyen-Ga

How fast can you count to this #?

We Need Your Help!

Do You Know This Scientist?

If you do, we welcome your input.  Please share your funny stories, brief anecdotes, quotes, and photos of the scientist - as well as your own inspirational opinions.  Personal accounts help bring a scientist alive and create an enduring historical picture.  You can be a part of this exciting history by providing your personal account! 

Please click here to learn more about how to contribute:
Participate as a Friend Scholar

Can You Write or Research?

Help us learn more about this great scientist.  You can be a credited Support Scholar by contributing your knowledge about this scientist and important discovery.  Entries can be as short as a single section and as easy as compiling quotes.  Click here to learn more about becoming a Support Scholar:
Participate as a Support Scholar

Would you like to adopt a scientist?

Endeavor to research all the sections of a scientist. Click here to learn how to be an Expert Scholar.
Participate as an Expert Scholar

Have Historically Significant Photographs?
Participate with Photos

Click here for all the ways you can participate:
Participate to ScienceHeroes.com

Testimonials

Has this scientist’s science impacted your life?
Click here to tell your story or to read others’ life changing anecdotes:
Post Your Own Testimonial


Nghe Nguyen-Ga
(dob - )
Born in
Year of Discovery: 1989

readitIntroAbove
scienceheronopic275w
New AIDS Drug Invented Has Far Fewer Side Effects

Nghe Nguyen-Ga teamed with Bernard Belleau to invent an effective alternative to the anti-AIDS drug AZT. Working together at the IAF BioChem International Inc., based in Montreal, the pair developed Lamivudine. Commonly referred to as 3TC, the new medication was a significant breakthrough in the fight against AIDS. Not only was 3TC effective in fighting AIDS, it had far fewer side effects than AZT.  This fact made it a popular choice with both patients and physicians. The drug was a major success, and is credited with saving over 2 million lives.

Human immunodeficiency virus (HIV) originated in West Africa, with the first confirmed case being recorded in 1959. The virus slowly spread across Africa and then, in the late 1970s and early 1980s, exploded throughout other parts of the world. HIV is the underlying cause of AIDS, a disease that attacks the immune system, and is passed from person to person through contact with bodily fluids. As AIDS progresses, individuals become less able to ward off infections and fall prey to a variety of diseases and infections that normally are easily fought off by the body. Among the common diseases initially associated with AIDS was Kaposi's sarcoma, a cancer that can affect both internal organs and the skin. Victims also began showing up at emergency rooms with a variety of flu-like symptoms and an unusual form of pneumonia known as pneumocystis. Health officials initially thought the disease was limited to homosexual men living in large metropolitan areas. But, they quickly discovered that both hemophiliacs and heterosexual intravenous drug users were also being infected. A French physician, Luc Montagnier, initially discovered that the underlying cause of AIDS was a retrovirus.,This was a major breakthrough, allowing other scientists to develop treatments, and AZT became the first drug approved to fight AIDS. The development of 3TC was a significant development, especially because of its fewer side effects, and it became a major force in the fight against AIDS.

At the time 3TC was developed, AZT was the only available treatment for AIDS. But, over 90 percent of those patients treated with AZT developed a resistance to it within the first year of treatment - and experienced significant damage to their immune systems. In developing 3TC, Nguyen-Ga and Belleau developed a treatment that would fight AIDS, but avoid the side effects of severe pain, bone marrow destruction, and anemia. 3TC works by preventing the HIV retrovirus from altering the cell's genetic structure. This retards the spread of AIDS within the body, as new cells are no longer susceptible. Though 3TC doesn't repair the damage already done to existing cells, it offers widespread protection to the remaining uninfected cells. Best of all, it achieves this without the debilitating side effects patients had previously experienced. 3TC proved to be even more effective when combined with lower doses of AZT. This combination was the first "cocktail" treatment to fight against AIDS.

readitIntroBelow

readitSeeTally

Introduction by Tim Anderson


Bookcoverjacket


Table of Contents

Introduction
Links to More Information About the Scientist
Key Insight
Key Experiment or Research
Key Contributors
Quotes by the Scientist
Quotes About the Scientist
Anecdotes
Fun Trivia About The Science
The Science Behind the Discovery
Personal Information
Science Discovery Timeline
Recommended Books About the Science
Books by the Scientist
Books About the Scientist
Awards
Major Academic Papers
Curriculum Vitae
Links to Science and Related Information on the Subject
Sources

 








Links to More About the Scientist & the Science

Wikipedia entry on Lamivudine referencing Nguyen-Ga:

Emory University news release announcing patent award for Lamivudine referencing Nguyen-Ga:

DrugsWell.com history of Lamivudine referencing Nguyen-Ga:



Sliders & Images here




Image Flow Here




Key Insight




Key Experiments or Research

 



Key Contributors

The Team
Explore other scientists who furthered this lifesaving advance.
Lifesavers: AIDS
Acquired Immune
Deficiency Syndrome
Luc Montagnier
Developed the blood test to detect HIV, the underlying cause of AIDS.
Françoise Barré-Sinoussi
A retrovirus expert, she was the first to isolate the AIDS virus.
Bernard Belleau
Co-developed the effective AIDS drug 3TC, which had fewer side effects than AZT.
Francesco Bellini
Co-developed the effective AIDS drug 3TC, which had fewer side effects than AZT.
Gervais Dionne
Co-developed the effective AIDS drug 3TC, which had fewer side effects than AZT.




Quotes by the Scientist




Quotes About the Scientist




Anecdotes




Fun Trivia About the Science




The Science Behind the Discovery



Personal Information



Scientific Discovery Timeline




Recommended Books About the Science




Books by the Scientist




Books About the Scientist

 



Awards




Major Academic Papers Written by the Scientist



Curriculum Vitae



Links to Information on the Science





Sources/References