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Kenneth Murray

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Kenneth Murray
(1931 - )
Born in England
Year of Discovery: 1969

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First Genetically Engineered Vaccine - Hepatitis B

An exciting medical discovery, originally considered "frightening" by government officials, eventually saved millions of lives. It also introduced to the medical community a microbiologist who would become known as the "Robin Hood" of medical research. Scotland's Kenneth Murray used his expertise in genetic engineering (the creation of new genes) to develop a vaccine for Hepatitis B, a devastating liver disease.

The liver is the largest solid organ inside the body, weighing over three pounds in the average adult. It's also one of the busiest organs, playing keys roles in detoxification, protein synthesis and digestion. Hepatitis B, a serious viral infection that damages the cells of the liver, was extremely difficult to treat prior to Murray's vaccine. In 1969, an outbreak of hepatitis B at a kidney transplant unit in Edinburgh, Scotland, highlighted the need for an effective treatment. Eleven people died because there was no vaccine available to fight this deadly disease. Across the city, Kenneth Murray, a molecular biologist, was shocked to learn about the nightmare faced by his medical colleagues. At the time, he was conducting research with his wife, Noreen, also a microbiologist. They were working in the emerging field of genetic engineering, devising ways to both create new genes and clone existing ones. This would prove to be crucial because, until then, hepatitis vaccines could only be made from the blood of hepatitis B carriers-a cumbersome and costly process that produced very limited supplies. But, if Murray could use his technology to re-create the hepatitis vaccine in the laboratory, then large-scale production of the vaccine would be possible.

Murray got a sample of the Hepatitis B virus from his colleagues in Edinburgh. He then set about the difficult task of careful study required to recreate the vaccine as a man-made product. But, this was not the only challenge with which Murray had to contend. Genetic engineering was so new and alarming, the government insisted his work be done under intense security and containment at a germ warfare center. In fact, safety concerns were so high at the time, the United States would not allow this type of research on human viruses at all! In November, 1978, they demonstrated they had successfully recreated the hepatitis antigens in the lab. This laid the foundation for development of a tool for diagnosing those infected by the virus and, most significantly, the development of a synthetic vaccine to fight against Hepatitis B. The vaccine would not only prove to be effective, but was safer and cheaper than vaccines derived from blood products. Over 300 million people around the world are infected with Hepatitis B, so Murray's breakthrough was a most welcome and significant advance.

Murray was a co-founder of the European company Biogen, which patented the Hepatitis B vaccine. The patents require the payment of royalties by drug companies using or adapting Murray's original discovery. It soon became obvious Murray's royalty earnings from this breakthrough would be significant-but, Murray had no interest in simple self-indulgence. Instead, Kenneth Murray used his share to establish the Darwin Trust, which supports educational and research activities in natural science. "I could have taken the money but I don't need to. I don't particularly want a Rolls- Royce," said Murray. "It has been a fairy story, I suppose. I have actually got a lot a satisfaction out of the trust." It is this generosity which earned him the affectionate title of the "Robin Hood" of medical research.

Murray received a great deal of recognition for his work with the Hepatitis B vaccine and for his dedication to medical research. He was even knighted for his discovery! But, even with the money and the recognition, Murray continued to dedicate himself to research. Hunched over his laboratory bench in pursuit of the next breakthrough, Murray could often be overheard saying, "Experiments don't do themselves."

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Introduction by April Ingram

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Table of Contents

Introduction
Links to More Information About the Scientist
Key Insight
Key Experiment or Research
Key Contributors
Quotes by the Scientist
Quotes About the Scientist
Anecdotes
Fun Trivia About The Science
The Science Behind the Discovery
Personal Information
Science Discovery Timeline
Recommended Books About the Science
Books by the Scientist
Books About the Scientist
Awards
Major Academic Papers
Curriculum Vitae
Links to Science and Related Information on the Subject
Sources

 








Links to More About the Scientist & the Science

The University of Edinburgh article on Murray:
http://www.research-innovation.ed.ac.uk/success/hepatitisB.asp

Newspaper article, "The million dollar microbe," about Murray's discovery (pdf):
http://www.60yearsofnhsscotland.co.uk/media/downloads/sources-hepatitis.pdf

Fungal biology, by Deacon, referencing Murray's research:



Sliders & Images here




Image Flow Here




Key Insight




Key Experiments or Research

 



Key Contributors

The Team
Explore other scientists who furthered this lifesaving advance.
Lifesavers: Hepatitis B
Baruch Blumberg
Discovered the antigen that causes hepatitis B; co-developed the vaccine to fight against it.
Irving Millman
His expertise in microbiology was critical in co-developing the hepatitis B vaccine.




Quotes by the Scientist




Quotes About the Scientist




Anecdotes




Fun Trivia About the Science




The Science Behind the Discovery



Personal Information



Scientific Discovery Timeline




Recommended Books About the Science




Books by the Scientist




Books About the Scientist

 



Awards




Major Academic Papers Written by the Scientist



Curriculum Vitae



Links to Information on the Science





Sources/References